TY - JOUR T1 - Salivary levels of Interleukin-6 and Tumor Necrosis Factor-alpha in girls aged 7–17 years practicing volleyball JO - Apunts Sports Medicine T2 - AU - Peres,Carolina da Silva AU - Gava,Roberta Pratti AU - Zen,Igor Renan AU - Correa,Julio Cesar Molina AU - Seixas,Gabriela Fleury AU - Silva,Carla Cristiane AU - Garbelini,Cassia Cilene Dezan AU - Ramos,Solange de Paula SN - 18866581 M3 - 10.1016/j.apunts.2019.07.003 DO - 10.1016/j.apunts.2019.07.003 UR - https://apunts.org/en-salivary-levels-interleukin-6-tumor-necrosis-articulo-S1886658119300131 AB - IntroductionThe purpose of the study was to evaluate the salivary concentrations of Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNFα) and correlate the findings with the caries index, body mass index (BMI), potency of lower limbs (vertical jump), cardiorespiratory fitness, and risk of developing cardiovascular diseases in girls practicing volleyball. Material and methodsTwo studies were performed: 1) a cross-sectional study (n=120) on the association of IL-6 and TNFα with the caries index, anthropometric measures, physical tests, and experience in volleyball practice; 2) longitudinal study (n=63) on the effects of 8 weeks of training on salivary IL-6 and TNFα in girls with intermediate experience in volleyball and competitive girls. ResultsThe median levels of IL-6 were 1.98 [1.55–3.11]pg/ml and TNFα, 0.46 [0.28–0.59]pg/ml and these did not correlate with the caries index, BMI, training volume, training practice, or cardiovascular risk. A correlation was observed between IL-6 and TNFα (r=0.34; p<0.001), IL-6 and vertical jump height (r=−0.28, p<0.005), and TNFα and age (r=0.33; p<0.001). After 8 weeks of training, TNFα levels increased in the intermediate and competitive groups (p<0.05), while IL-6 levels decreased only in the intermediate level group (p<0.05). Conclusionthe median levels of IL-6 and TNFα did not correlate with the caries index, BMI, training volume, experience practice, or cardiovascular risk. Salivary levels of IL-6 were downmodulated in the group with intermediate experience and TNFα was upmodulated by training. ER -