THE EFFECT OF PHYSICAL CONDITIONING SUGGESTS ADAPTATION IN PROCOAGULANT AND FIBRINOLYTIC POTENTIAL
Section snippets
Subjects
In a cross-sectional study design, two groups of subjects with different aerobic endurance levels were tested. The first group included eight male long-distance runners (athletes) who had competed in national events for more than 5 years. They were tested in June while undergoing intense training (11.5 ± 1.0 hour·week−1 ; 8.3 ± 0.6 training units·week−1) and at least one competitive event per week. Their training program during this period included intense interval training. The second group
Baseline characteristics and responses to physical exercise
The data of the two groups of subjects are given in Table 1. Significantly higher plasma lactate levels after exercise were demonstrated in controls compared to athletes, eventhough both groups were tested at 80 % of their VO2 max. However, the plasma lactate levels in both groups failed to correlate with the levels of F1+2, TAT, tPA, and PAI-1 both before and after standardized exercise (r<0.3, p>0.1).
Procoagulant potential
F1+2. There was a significant increase in F1+2 level among controls in response to
DISCUSSION
The present study suggests more pronounced activation of the coagulation system among controls compared to athletes in response to physical exercise, as evaluated by the post-exercise increase in F1+2. The amount of thrombin generated in response to exercise appears to be rather small, explaining the limited increase in F1+2. This is also supported by the fact that the level of TAT, another marker of in vivo coagulation, did not change significantly in response to exercise in this study. The
Acknowledgements
This study was supported by the Norwegian Research Council for Science and the Humanities. We are indebted to Karin Lia for excellent technical assistance, and to Sara El-Gewely for correcting the English.
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