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ens vam plantejar determinar si hi ha algun tipus de correlaci&#243; estad&#237;sticament significativa entre certes condicions meteorol&#242;giques &#40;temperatura&#44; humitat i pressi&#243; barom&#232;trica&#41; i la pres&#232;ncia de simptomatologia en pacients amb artrosi &#40;dolor articular i incapacitat funcional&#41;&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> M&#232;todes</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Descripci&#243; de l&#39;estudi</span></p><p class="elsevierStylePara"> Aquest treball es va dur a terme amb pacients de l&#39;Institut Poal de Reumatologia de Barcelona&#44; i les dades van ser analitzades per la Unitat de Salut Articular del Departament M&#232;dic i Cient&#237;fic de Bioib&#233;rica Farma&#46; Va consistir en un estudi observacional&#44; prospectiu&#44; a doble cec&#44; que va incloure 80 pacients amb artrosi comparats amb un grup control de 42 subjectes&#46; L&#39;estudi es va fer a l&#39;&#224;rea metropolitana de Barcelona&#44; que es caracteritza per un clima t&#237;picament mediterrani&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Par&#224;metres de valoraci&#243;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic"> Simptomatologia de l&#39;artrosi</span></span></p><p class="elsevierStylePara"> Cada pacient va rebre un q&#252;estionari &#40;Health Assessment Questionnaire &#91;HAQ&#93;&#41; que havia d&#39;emplenar di&#224;riament durant 31 dies consecutius&#46; Aquest q&#252;estionari consisteix en una s&#232;rie de preguntes referents a la capacitat funcional del pacient amb l&#39;objectiu de determinar el grau de dificultat per fer certes activitats quotidianes &#40;vestir-se&#44; ajeure&#39;s al llit i aixecar-se&#39;n&#44; obrir i tancar una aixeta&#44; etc&#46;&#41;&#46; Els resultats possibles s&#243;n&#58; 0 &#40;cap dificultat&#41;&#44; 1 &#40;certa dificultat&#41;&#44; 2 &#40;dificultat important&#41; o 4 &#40;impossible de fer l&#39;activitat&#41;&#46; L&#39;HAQ tamb&#233; inclou l&#39;escala anal&#242;gica visual &#40;EAV&#41; de Huskisson de 0 a 100 mm per a l&#39;avaluaci&#243; del dolor articular&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Variables meteorol&#242;giques</span></span></p><p class="elsevierStylePara"> Les variables meteorol&#242;giques estudiades van ser&#58;</p><p class="elsevierStylePara">&#8226; Temperatura&#46;</p><p class="elsevierStylePara">&#8226; Humitat&#46;</p><p class="elsevierStylePara">&#8226; Pressi&#243; atmosf&#232;rica&#46;</p><p class="elsevierStylePara">La Unitat de Salut Articular del Departament M&#232;dic i Cient&#237;fic de Bioib&#233;rica Farma recollia aquestes dades di&#224;riament&#44; a trav&#233;s del web del Servei Catal&#224; de Meteorologia &#40;http&#58;&#47;&#47;www&#46;gencat&#46;&#233;s&#47;servmet&#41;&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">An&#224;lisi estad&#237;stica</span></p><p class="elsevierStylePara"> L&#39;an&#224;lisi estad&#237;stica de les dades es va fer mitjan&#231;ant els programes estad&#237;stics SPPS &#40;Statistical Package for the Social Sciences&#41; i StatXact&#46; Les variables quantitatives &#40;EAV de Huskisson&#44; HAQ&#44; edat&#44; pes&#44; hores de ter&#224;pia&#41; van ser analitzades amb un test de Kruskal-Wallis i ANOVA&#44; i les qualitatives &#40;sexe&#44; treball&#44; exploraci&#243; f&#237;sica&#41; amb el test de Fisher&#46; Per determinar les possibles correlacions entre els diversos par&#224;metres estudiats&#44; es va fer una an&#224;lisi de multivari&#224;ncia&#46;</p><p class="elsevierStylePara">Es va triar el model de regressi&#243; bin&#224;ria per examinar la correlaci&#243; entre les variables cl&#237;niques i les meteorol&#242;giques&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Resultats</span></p><p class="elsevierStylePara"> Les nostres dades demostren que els pacients artr&#242;sics tenen un increment del dolor articular en resposta a una disminuci&#243; de la pressi&#243;&#44; la qual cosa indica que condicions baixes de pressi&#243; atmosf&#232;rica poden intensificar el dolor articular en aquests pacients &#40;taula I&#44; fig&#46; 1&#41;&#46; En canvi&#44; aquesta correlaci&#243; no s&#39;observa amb la humitat o amb la temperatura&#46;</p><p class="elsevierStylePara"><img src="278v42n155-13112539tab01.gif"></img></p><p class="elsevierStylePara"><img src="278v42n155-13112539tab02.gif"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figura 1</span> Resum esquem&#224;tic de l&#39;efecte de les condicions meteorol&#242;giques en pacients amb artrosi&#46;</p><p class="elsevierStylePara">La capacitat funcional dels pacients no es veu modificada d&#39;una manera estad&#237;sticament significativa per cap de les 3 condicions clim&#224;tiques estudiades &#40;taula II&#41;&#46; En concret&#44; s&#39;observa un certa correlaci&#243; entre la incapacitat funcional i la humitat &#40;p &#60; 0&#44;05&#41;&#44; per&#242; no &#233;s concloent&#44; at&#232;s que l&#39;interval de confian&#231;a &#40;IC&#41; del 95&#37; est&#224; molt pr&#242;xim a l&#39;<span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41;&#46;</p><p class="elsevierStylePara"><img src="278v42n155-13112539tab03.gif"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Discussi&#243;</span></p><p class="elsevierStylePara">En una revisi&#243;&#44; publicada per Jamison<span class="elsevierStyleSup">11</span>&#44; dels efectes de les condicions meteorol&#242;giques sobre el dolor&#44; es proposen diversos mecanismes que podrien explicar-ne els efectes&#44; com ara determinats factors fisiol&#242;gics associats amb canvis en el clima&#44; que podrien tenir una repercussi&#243; en subjectes amb dolor cr&#242;nic&#46; D&#39;altra banda&#44; modificacions de la pressi&#243; barom&#232;trica tamb&#233; podrien induir un desequilibri temporal en la pressi&#243; corporal que sensibilitzaria les terminacions nervioses&#44; i causar un increment en el dolor precedent als canvis de temperatura o humitat&#46; A m&#233;s&#44; els nostres resultats tamb&#233; concorden amb els experiments realitzats per alguns cl&#237;nics que defineixen aquests pacients com a pacients barom&#232;trics&#46;</p><p class="elsevierStylePara">En un estudi de Verjurats et al<span class="elsevierStyleSup">12</span> tamb&#233; es demostra que algunes variables meteorol&#242;giques incideixen en l&#39;aparici&#243; del dolor en l&#39;artritis reumatoide&#44; ja que es va observar que el descens de la temperatura augmenta el risc de dolor articular&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Conclusi&#243;</span></p><p class="elsevierStylePara"> Aquestes dades&#44; obtingudes a l&#39;&#224;rea metropolitana de Barcelona&#44; suggereixen que determinats pacients afectats de condropaties greus responen a una reducci&#243; de la pressi&#243; atmosf&#232;rica amb un increment del dolor articular&#46;</p><p class="elsevierStylePara">A partir d&#39;aquestes dades cl&#237;niques no &#233;s dif&#237;cil pensar que en el tractament d&#39;esportistes que pateixen diverses condropaties existeixi tamb&#233; una correlaci&#243; entre les condicions meteorol&#242;giques i el dolor en les articulacions&#46; Per tant&#44; sembla interessant emprendre un estudi semblant al que es presenta&#44; per&#242; m&#233;s enfocat a la medicina esportiva&#46; D&#39;aquesta manera&#44; en el futur podria ser possible modular els tractaments no farmacol&#242;gics i farmacol&#242;gics per a alguns pacients amb patologia condral en funci&#243; de la previsi&#243; meteorol&#242;gica i evitar&#44; en la mesura possible&#44; el dolor articular i la incapacitat funcional associats a la malaltia&#44; i millorar&#44; doncs&#44; la qualitat de vida d&#39;aquests pacients&#46;</p><hr></hr><p class="elsevierStylePara"> Correspond&#232;ncia&#58; Josep Verg&#233;s&#46; Departament M&#232;dic i Cient&#237;fic&#46; Bioib&#233;rica Farma&#46; Pla&#231;a Francesc Maci&#224;&#44; 7&#46; 08029 Barcelona&#46; Espanya&#46;<br></br> Correu electr&#242;nic&#58; <a href="mailto&#58;jverges&#64;bioiberica&#46;com" class="elsevierStyleCrossRefs"> jverges&#64;bioiberica&#46;com</a></p>"
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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;&#58;</span> En la pr&#224;ctica cl&#237;nica habitual&#44; molts pacients atribueixen el dolor articular a certes condicions meteorol&#242;giques&#46; <span class="elsevierStyleBold">Objectiu&#58;</span> Avaluar l&#39;efecte de les condicions clim&#224;tiques en pacients amb artrosi&#46; <span class="elsevierStyleBold">M&#232;todes&#58;</span> Aquest treball es va realitzar amb pacients de l&#39;Institut Poal de Reumatologia de Barcelona i les dades van ser analitzats per Bioib&#233;rica Farma&#46; Va consistir en un estudi prospectiu&#44; a doble cec&#44; que va incloure 80 pacients amb artrosi&#44; comparats amb un grup control de 42 subjectes&#46; L&#39;avaluaci&#243; del dolor &#40;EAV de Huskisson&#41; i la capacitat funcional &#40;HAQ&#41; es van determinar di&#224;riament durant un mes&#44; i les variables clim&#224;tiques estudiades van ser la temperatura&#44; la humitat i la pressi&#243; atmosf&#232;rica&#46; <span class="elsevierStyleBold">Resultats&#58;</span> Les nostres dades demostren que els pacients artr&#242;sics tenen un augment del dolor articular en resposta a una disminuci&#243; de la pressi&#243;&#44; la qual cosa indica que les condicions de baixa pressi&#243; atmosf&#232;rica exacerben el dolor en aquests pacients&#46; <span class="elsevierStyleBold">Conclusi&#243;&#58;</span> Aquestes dades suggereixen que en el futur podria ser factible modular els tractaments farmacol&#242;gics i no farmacol&#242;gics per a alguns pacients artr&#242;sics en funci&#243; de la previsi&#243; meteorol&#242;gica i evitar&#44; en la mesura possible&#44; el dolor articular i la incapacitat funcional associats a la malaltia&#44; tot millorant la qualitat de vida d&#39;aquests pacients&#46;"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#58;</span> In routine clinical practice&#44; many patients attribute their joint pain to the weather&#46; <span class="elsevierStyleBold">Objective&#58;</span> To evaluate the effect of climatic conditions in patients with osteoarthritis&#46; <span class="elsevierStyleBold">Methods&#58;</span> This study was performed in patients from the Institut Poal de Reumatologia in Barcelona and the data were analyzed by Bioib&#233;rica Farma&#46; We performed a prospective&#44; double-blind study that included 80 patients with osteoarthritis who were compared with 42 controls&#46; Pain evaluation &#40;Huskisson&#39;s Visual Analogue Scale&#41; and functional capacity &#40;Health Assessment Questionnaire&#41; were determined daily for 1 month&#46; The climatic variables studied were temperature&#44; humidity&#44; and atmospheric pressure&#46; <span class="elsevierStyleBold">Results&#58;</span> Our data show that patients with osteoarthritis have greater joint pain when atmospheric pressure is lower&#44; indicating that conditions of low atmospheric pressure exacerbate pain in these patients&#46; <span class="elsevierStyleBold">Conclusion&#58;</span> Our results suggest that&#44; in future&#44; modulation of pharmacological and nonpharmacological therapy in some osteoarthritic patients according to weather forecasts may be feasible&#46; This could avoid&#44; as far as possible&#44; the joint pain and functional disability associated with the disease&#44; thus improving quality of life in these patients&#46;"
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Influència de les condicions meteorològiques en la patologia condral
Influence of climatic conditions in chondral disease
Josep Vergésa, Eulàlia Montella, Elena Tomàsa, Carolina Coronasa, Gemma Cumellesa, Guido Castañedaa, Núria Martíb, Ingrid Möllerb
a Unitat de Salut Articular. Departament Mèdic i Científic. Bioibérica Farma. Barcelona. Espanya.
b Institut Poal de Reumatologia. Barcelona. Espanya.
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    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"> Introducci&#243;</span></p><p class="elsevierStylePara">En la pr&#224;ctica cl&#237;nica habitual&#44; molts pacients atribueixen el dolor articular o la incapacitat funcional a certes condicions meteorol&#242;giques&#46; Hi ha poca informaci&#243; publicada sobre aix&#242; i la majoria &#233;s contradict&#242;ria<span class="elsevierStyleSup">1-8</span>&#46; Laborde et al<span class="elsevierStyleSup">9</span> van demostrar que la pluja afecta el grau de dolor en pacients amb artrosi que viuen a zones urbanes&#46; Tanmateix&#44; les dades publicades per Sibley<span class="elsevierStyleSup">3</span> no reflecteixen cap correlaci&#243; entre les condicions meteorol&#242;giques i els s&#237;mptomes de la patologia artr&#242;sica&#46; Darrerament&#44; en un estudi realitzat per Hashkes<span class="elsevierStyleSup">10</span>&#44; es va observar que una ter&#224;pia clim&#224;tica indu&#239;a una millora temporal en els pacients amb artritis inflamat&#242;ria&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Objectiu</span></p><p class="elsevierStylePara"> L&#39;objectiu d&#39;aquest estudi va ser avaluar l&#39;efecte de les condicions clim&#224;tiques en pacients amb artrosi&#46;</p><p class="elsevierStylePara"> Concretament&#44; ens vam plantejar determinar si hi ha algun tipus de correlaci&#243; estad&#237;sticament significativa entre certes condicions meteorol&#242;giques &#40;temperatura&#44; humitat i pressi&#243; barom&#232;trica&#41; i la pres&#232;ncia de simptomatologia en pacients amb artrosi &#40;dolor articular i incapacitat funcional&#41;&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> M&#232;todes</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Descripci&#243; de l&#39;estudi</span></p><p class="elsevierStylePara"> Aquest treball es va dur a terme amb pacients de l&#39;Institut Poal de Reumatologia de Barcelona&#44; i les dades van ser analitzades per la Unitat de Salut Articular del Departament M&#232;dic i Cient&#237;fic de Bioib&#233;rica Farma&#46; Va consistir en un estudi observacional&#44; prospectiu&#44; a doble cec&#44; que va incloure 80 pacients amb artrosi comparats amb un grup control de 42 subjectes&#46; L&#39;estudi es va fer a l&#39;&#224;rea metropolitana de Barcelona&#44; que es caracteritza per un clima t&#237;picament mediterrani&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Par&#224;metres de valoraci&#243;</span></p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic"> Simptomatologia de l&#39;artrosi</span></span></p><p class="elsevierStylePara"> Cada pacient va rebre un q&#252;estionari &#40;Health Assessment Questionnaire &#91;HAQ&#93;&#41; que havia d&#39;emplenar di&#224;riament durant 31 dies consecutius&#46; Aquest q&#252;estionari consisteix en una s&#232;rie de preguntes referents a la capacitat funcional del pacient amb l&#39;objectiu de determinar el grau de dificultat per fer certes activitats quotidianes &#40;vestir-se&#44; ajeure&#39;s al llit i aixecar-se&#39;n&#44; obrir i tancar una aixeta&#44; etc&#46;&#41;&#46; Els resultats possibles s&#243;n&#58; 0 &#40;cap dificultat&#41;&#44; 1 &#40;certa dificultat&#41;&#44; 2 &#40;dificultat important&#41; o 4 &#40;impossible de fer l&#39;activitat&#41;&#46; L&#39;HAQ tamb&#233; inclou l&#39;escala anal&#242;gica visual &#40;EAV&#41; de Huskisson de 0 a 100 mm per a l&#39;avaluaci&#243; del dolor articular&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"><span class="elsevierStyleItalic">Variables meteorol&#242;giques</span></span></p><p class="elsevierStylePara"> Les variables meteorol&#242;giques estudiades van ser&#58;</p><p class="elsevierStylePara">&#8226; Temperatura&#46;</p><p class="elsevierStylePara">&#8226; Humitat&#46;</p><p class="elsevierStylePara">&#8226; Pressi&#243; atmosf&#232;rica&#46;</p><p class="elsevierStylePara">La Unitat de Salut Articular del Departament M&#232;dic i Cient&#237;fic de Bioib&#233;rica Farma recollia aquestes dades di&#224;riament&#44; a trav&#233;s del web del Servei Catal&#224; de Meteorologia &#40;http&#58;&#47;&#47;www&#46;gencat&#46;&#233;s&#47;servmet&#41;&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold">An&#224;lisi estad&#237;stica</span></p><p class="elsevierStylePara"> L&#39;an&#224;lisi estad&#237;stica de les dades es va fer mitjan&#231;ant els programes estad&#237;stics SPPS &#40;Statistical Package for the Social Sciences&#41; i StatXact&#46; Les variables quantitatives &#40;EAV de Huskisson&#44; HAQ&#44; edat&#44; pes&#44; hores de ter&#224;pia&#41; van ser analitzades amb un test de Kruskal-Wallis i ANOVA&#44; i les qualitatives &#40;sexe&#44; treball&#44; exploraci&#243; f&#237;sica&#41; amb el test de Fisher&#46; Per determinar les possibles correlacions entre els diversos par&#224;metres estudiats&#44; es va fer una an&#224;lisi de multivari&#224;ncia&#46;</p><p class="elsevierStylePara">Es va triar el model de regressi&#243; bin&#224;ria per examinar la correlaci&#243; entre les variables cl&#237;niques i les meteorol&#242;giques&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Resultats</span></p><p class="elsevierStylePara"> Les nostres dades demostren que els pacients artr&#242;sics tenen un increment del dolor articular en resposta a una disminuci&#243; de la pressi&#243;&#44; la qual cosa indica que condicions baixes de pressi&#243; atmosf&#232;rica poden intensificar el dolor articular en aquests pacients &#40;taula I&#44; fig&#46; 1&#41;&#46; En canvi&#44; aquesta correlaci&#243; no s&#39;observa amb la humitat o amb la temperatura&#46;</p><p class="elsevierStylePara"><img src="278v42n155-13112539tab01.gif"></img></p><p class="elsevierStylePara"><img src="278v42n155-13112539tab02.gif"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figura 1</span> Resum esquem&#224;tic de l&#39;efecte de les condicions meteorol&#242;giques en pacients amb artrosi&#46;</p><p class="elsevierStylePara">La capacitat funcional dels pacients no es veu modificada d&#39;una manera estad&#237;sticament significativa per cap de les 3 condicions clim&#224;tiques estudiades &#40;taula II&#41;&#46; En concret&#44; s&#39;observa un certa correlaci&#243; entre la incapacitat funcional i la humitat &#40;p &#60; 0&#44;05&#41;&#44; per&#242; no &#233;s concloent&#44; at&#232;s que l&#39;interval de confian&#231;a &#40;IC&#41; del 95&#37; est&#224; molt pr&#242;xim a l&#39;<span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41;&#46;</p><p class="elsevierStylePara"><img src="278v42n155-13112539tab03.gif"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Discussi&#243;</span></p><p class="elsevierStylePara">En una revisi&#243;&#44; publicada per Jamison<span class="elsevierStyleSup">11</span>&#44; dels efectes de les condicions meteorol&#242;giques sobre el dolor&#44; es proposen diversos mecanismes que podrien explicar-ne els efectes&#44; com ara determinats factors fisiol&#242;gics associats amb canvis en el clima&#44; que podrien tenir una repercussi&#243; en subjectes amb dolor cr&#242;nic&#46; D&#39;altra banda&#44; modificacions de la pressi&#243; barom&#232;trica tamb&#233; podrien induir un desequilibri temporal en la pressi&#243; corporal que sensibilitzaria les terminacions nervioses&#44; i causar un increment en el dolor precedent als canvis de temperatura o humitat&#46; A m&#233;s&#44; els nostres resultats tamb&#233; concorden amb els experiments realitzats per alguns cl&#237;nics que defineixen aquests pacients com a pacients barom&#232;trics&#46;</p><p class="elsevierStylePara">En un estudi de Verjurats et al<span class="elsevierStyleSup">12</span> tamb&#233; es demostra que algunes variables meteorol&#242;giques incideixen en l&#39;aparici&#243; del dolor en l&#39;artritis reumatoide&#44; ja que es va observar que el descens de la temperatura augmenta el risc de dolor articular&#46;</p><p class="elsevierStylePara"><span class="elsevierStyleBold"> Conclusi&#243;</span></p><p class="elsevierStylePara"> Aquestes dades&#44; obtingudes a l&#39;&#224;rea metropolitana de Barcelona&#44; suggereixen que determinats pacients afectats de condropaties greus responen a una reducci&#243; de la pressi&#243; atmosf&#232;rica amb un increment del dolor articular&#46;</p><p class="elsevierStylePara">A partir d&#39;aquestes dades cl&#237;niques no &#233;s dif&#237;cil pensar que en el tractament d&#39;esportistes que pateixen diverses condropaties existeixi tamb&#233; una correlaci&#243; entre les condicions meteorol&#242;giques i el dolor en les articulacions&#46; Per tant&#44; sembla interessant emprendre un estudi semblant al que es presenta&#44; per&#242; m&#233;s enfocat a la medicina esportiva&#46; D&#39;aquesta manera&#44; en el futur podria ser possible modular els tractaments no farmacol&#242;gics i farmacol&#242;gics per a alguns pacients amb patologia condral en funci&#243; 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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;&#58;</span> En la pr&#224;ctica cl&#237;nica habitual&#44; molts pacients atribueixen el dolor articular a certes condicions meteorol&#242;giques&#46; <span class="elsevierStyleBold">Objectiu&#58;</span> Avaluar l&#39;efecte de les condicions clim&#224;tiques en pacients amb artrosi&#46; <span class="elsevierStyleBold">M&#232;todes&#58;</span> Aquest treball es va realitzar amb pacients de l&#39;Institut Poal de Reumatologia de Barcelona i les dades van ser analitzats per Bioib&#233;rica Farma&#46; Va consistir en un estudi prospectiu&#44; a doble cec&#44; que va incloure 80 pacients amb artrosi&#44; comparats amb un grup control de 42 subjectes&#46; L&#39;avaluaci&#243; del dolor &#40;EAV de Huskisson&#41; i la capacitat funcional &#40;HAQ&#41; es van determinar di&#224;riament durant un mes&#44; i les variables clim&#224;tiques estudiades van ser la temperatura&#44; la humitat i la pressi&#243; atmosf&#232;rica&#46; <span class="elsevierStyleBold">Resultats&#58;</span> Les nostres dades demostren que els pacients artr&#242;sics tenen un augment del dolor articular en resposta a una disminuci&#243; de la pressi&#243;&#44; la qual cosa indica que les condicions de baixa pressi&#243; atmosf&#232;rica exacerben el dolor en aquests pacients&#46; <span class="elsevierStyleBold">Conclusi&#243;&#58;</span> Aquestes dades suggereixen que en el futur podria ser factible modular els tractaments farmacol&#242;gics i no farmacol&#242;gics per a alguns pacients artr&#242;sics en funci&#243; de la previsi&#243; meteorol&#242;gica i evitar&#44; en la mesura possible&#44; el dolor articular i la incapacitat funcional associats a la malaltia&#44; tot millorant la qualitat de vida d&#39;aquests pacients&#46;"
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ISSN: X8866581
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