Publish in this journal
Journal Information
Vol. 55. Issue 205.
Pages 21-27 (January - March 2020)
Download PDF
More article options
Vol. 55. Issue 205.
Pages 21-27 (January - March 2020)
Original Article
Concurrent exercise training and Murf-l and Atrogin-1 gene expression in the vastus lateralis muscle of male Wistar rats
Yashar Moradia, Farzad Zehsaza,
Corresponding author

Corresponding author.
, Mir Alireza Nourazarb
a Department of Physical Education and Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
b Department of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Article information
Full Text
Download PDF
Figures (1)
Tables (3)
Table 1. Endurance exercises protocol.
Table 2. Primer sequences.
Table 3. Comparison of the weight and gene expression of Murf-1 and Atrogin-1 after 8-week of intervention.
Show moreShow less

The present study was to determine the effect of 8-week of the concurrent exercise training on Murf-l and Atrogin-1 Gene Expression of the vastus lateralis muscle in male Wistar rats.

Material and methods

This study was conducted as an experimental project consisting of four groups of 35 two-month-old male Wistar rats. The animals were randomly divided in 4 groups: (1) endurance training, (2) resistance training, (3) combined training, and (4) control. The animals in the training groups took part in training programs for 8-week. 48h after the last exercise session, the Murf-1 and Atrogin-1 genes of the vastus lateralis muscle were examined through the use of qPCR method.


The results obtained from this study revealed that after 8-week of endurance exercise, Murf-1 and Arogin-1 gene expression significantly increased compared to the control group (p=0.04 and p=0.043). In contrast, in the resistance training group, the gene expression of Murf-1 and Atrogin-1 decreased significantly in comparison with the control group (p=0.02 and p=0.04). In addition, the concurrent training group showed no difference in Murf-1 and Atrogin-1 gene expression after 8-week of exercise compared to that of the control group (p=0.43 and p=0.38).


Based on the results of the present research, it can be expressed that resistance training prevents muscular atrophy by decreasing Murf-1 and Atrogin-1 gene expression. Conversely, endurance exercises cause an increase in the expression of these genes, thereby leading to atrophy in the muscles. The results also showed that concurrent exercises do not have a meaningful effect on muscular atrophy.

Gene expression
Endurance training
Resistance training


These are the options to access the full texts of the publication Apunts Sports Medicine

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Apunts Sports Medicine

Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Apunts Sports Medicine

Subscribe to our newsletter

Article options

Are you a health professional able to prescribe or dispense drugs?