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Vol. 56. Issue 210.
(April - June 2021)
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Vol. 56. Issue 210.
(April - June 2021)
Original Article
Effect of high intensity interval training on antioxidant status, inflammatory response and muscle damage indices in endurance team male players
Surojit Sarkara, Monalisa Debnatha, Moumita Dasa,b, Amit Bandyopadhyayc, Swapan Kr Deyd, Gouriprosad Dattaa,
Corresponding author

Corresponding author.
a Department of Physiology, Rammohan College, Kolkata, India
b Department of Applied Nutrition and Dietetics, Sister Nivedita University, Kolkata, India
c Sports and Exercise Physiology Laboratory, Department of Physiology, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Kolkata 700009, India
d Department of Sports Science, University of Calcutta, India
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Tables (7)
Table 1. Details of training programme including type, sessions, intensity of exercise.
Table 2. Comparison of anthropometric variables between pre- and post-HIIT intervention phases.
Table 3. Comparison of skeletal muscle damage indices, inflammatory markers, and cortisol level between pre- and post-HIIT intervention phases.
Table 4. Comparison of oxidative stress markers between pre- and post-HIIT intervention phases.
Table 5. Comparison of selective physical fitness variables between pre- and post-HIIT intervention phase.
Table 6. Pearson's product moment correlation coefficient of muscle damage indices, inflammatory markers, and oxidative stress markers with physical fitness variables in HIIT group players.
Table 7. Prediction of regression coefficient based on the linear regression model of young male team-game players.
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High-intensity interval training (HIIT) has previously been reported having the effect of training period on altering oxidant status, muscle damage and performance. The present study was aimed to understand and evaluate the adaptive response of 8 weeks HIIT on muscle damage indices, inflammatory markers, oxidative stress variables and physical fitness parameters.


Forty young endurance male players [i.e., football (n=20) and field hockey (n=20)] were recruited under two groups i.e., control and HIIT. 8 weeks long 3h/day of sprint-HIIT was intervened for thrice/week. HIIT workouts includes total 4 sets/session (divided into 2 phase×2 sets×2min) of all-out sprint workout (at 90–95% of HRmax with work: rest=1:1). Muscle damage indices (CK and LDH), inflammatory markers (IL-6 and TNF-α), oxidative stress variables (MDA, SOD, GSH and GPx) and physical fitness variables (VO2max, Wpeak and VJ) were assessed via following standard protocols.


The HIIT resulted to significantly(p<0.001) increase BMI (1.1%), LDH (15.0%), CK (14.4%), cortisol (9.4%), IL-6 (15.7%), TNF-α (18.2%), MDA (29.5%), VO2max (13.6%), Wpeak (11.6%), VJ (11.2%) and GPx (0.4%) along with significant (p<0.001) reduction in BF% (7.6%), SOD (11.1%), GSH (10.8%) content of athletes.


Antioxidant redox imbalance confers inflammatory oxidative stress condition which further leads to muscle damage and that may cause due to HIIT induced temporary hypoxic condition which contrarily induced overtraining effect but with improving performance variables.

Muscular damage
Oxidative stress
Sprint interval training


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